• br Autophagy at the Synapse The synapse is a highly

  2024-01-27

  

  Autophagy at the Synapse The synapse is a highly specialized neuronal compartment that forms the basic unit of communication between neurons. Communication relies on electrical signals that are propagated down the axon of the presynaptic neuron, where they trigger the quantal release of neurotran

• Whole body loss of ACLY is early embryonic lethal

  2024-01-27

  

  Whole-body loss of ACLY is early embryonic lethal, indicating that it serves non-redundant roles during development (Beigneux et al., 2004). Silencing or inhibition of ACLY suppresses the proliferation of many cancer cell lines and impairs tumor growth (Bauer et al., 2005, Hanai et al., 2012, Hatziv

• Mitochondrial dysfunction resulting from mtDNA abnormalities

  2024-01-26

  

  Mitochondrial dysfunction resulting from mtDNA abnormalities may trigger retrograde signaling pathways from the mitochondrion to the nucleus, which regulate the expression of genes involved in diverse cellular processes, including metabolism, stress responses, tumor progression, nutrient sensing, li

• br Implementation of sacubitril valsartan into clinical prac

  2024-01-26

  

  Implementation of sacubitril/valsartan into clinical practice Following on from the results of PARADIGM-HF, sacubitril/valsartan was given regulatory approval for use in patients who conform to the main inclusion criteria of the trial; NYHA functional class II–IV, reduced left ventricular ejectio

• br Acknowledgments br Introduction Amyloid deposit

  2024-01-26

  

  Acknowledgments Introduction Amyloid deposit formation is defined by the aggregation of β-sheeted forms of proteins that appear as starch-like amorphous material [1], [2]. Using a Kongo red stain, amyloids show birefringence behavior and an apple-green to reddish multicolor emission. Extracere

• When a clinician diagnoses a person with AD

  2024-01-26

  

  When a clinician diagnoses a person with AD, the person is transformed into a patient with the disease. The person is a member of a patient group associated with behaviors, abilities, and experiences related both formally and informally to the diagnosis [10]. The diagnostic label implies what signs

• Salvia the largest genus in the family Lamiaceae comprises o

  2024-01-26

  

  Salvia, the largest genus in the family Lamiaceae, comprises over 900 species that are distributed globally [14], [15], [16]. The genus Salvia has been assessed in many studies because it is a rich source of polyphenol compounds, of which more than 160 have been isolated from plants in the genus, so

• br Conclusions Several lines of evidence have been establish

  2024-01-26

  

  Conclusions Several lines of evidence have been established, which support the adenosine kinase hypothesis of epileptogenesis, which is based on a sequence of events leading from acute Phosphoramidon Disodium Salt injury to initial downregulation of ADK, rise in extracellular adenosine, changes i

• br Results br Discussion To achieve quantitative understandi

  2024-01-26

  

  Results Discussion To achieve quantitative understanding of Ro 48-8071 sale turnover, we utilize rapidly moving lamellipodial fragments that are geometrically simple, structurally homogeneous, and persistent, and measure relevant rates and concentrations in this system. We find that the lamel

• 7ACC2 br Actin at presynapses br

  2024-01-26

  

  Actin at presynapses Conclusion Thanks to the recent discovery of rings, hotspots and trails, axonal 7ACC2 is back in the spotlight. These are exiting times for neuronal cell biologists armed with constantly improving labeling and imaging techniques to observe, quantify and perturb these stru

• br Experimental section br Conflicts of interest br

  2024-01-26

  

  Experimental section Conflicts of interest Acknowledgments This work was partly supported by INSA-Rouen, Rouen University, CNRS, Labex SynOrg (ANR-11-LABX-0029), Région Haute-Normandie. Introduction A key component of the integrated management of key pests such as codling moth (Cydia po

• This raises an important question

  2024-01-26

  

  This raises an important question: May the lack of ethnolinguistic theories and of explicit references to language be related to the lack of contact with other groups and their languages? For the past few centuries at least, the Aché seem to have been culturally and linguistically isolated (Hill and

• A combination of factors might however account

  2024-01-26

  

  A combination of factors might, however, account for the low rate of success of drug development for neuropsychiatric disorders. First, in most neuropsychiatric disorders, the symptomatology is heterogeneous and the neurobiology remains poorly understood, making therapeutic targets difficult to ide

• br AD and COX LOX pharmacology

  2024-01-26

  

  AD and COX/5-LOX pharmacology Early studies on the role of cyclooxygenases in AD were inspired by epidemiological data suggesting that COX inhibitors such as nonsteroidal anti-inflammatory drugs (NSAIDs) could be beneficial in AD patients (Lucca et al., 1994, McGeer et al., 1990). This line of re

• br Co http www apexbt com media diy images wb

  2024-01-26

  

  Conclusions This paper is the first meta-analysis about the association between SRD5A2 V89L polymorphism and hypospadias risk. The results of this meta-analysis have revealed that V89L polymorphism definitely increases the risk of hypospadias, and the C allele is a genetic risk factor for hypospa

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