• Targeting a specific cell type rather than the broad cytotox

  2021-04-07

  

  Targeting a specific cell type, rather than the broad cytotoxicity exhibited by some of the pharmacological agents currently used to treat lupus, may improve efficacy and decrease off target toxicity. Thus, evidence that macrophages and microglia are important to the pathogenesis of LN and NPSLE, re

• CPH models reported usually as lists of

  2021-04-07

  

  CPH models, reported usually as lists of risk factors along with their parameters, are prevalent in medical literature. One such model is the CPH model created for the purpose of predicting the probability of one year survival of patients suffering from Pulmonary Arterial Hypertension [5]. The model

• In contrast irinotecan has shown much less myelosuppression

  2021-04-07

  

  In contrast, irinotecan has shown much less myelosuppression and may be more active in Ewing sarcoma both alone and in combination with temozolamide. One phase II study of 13 heavily pretreated Ewing sarcoma patients demonstrated a response rate of 38% including 2 complete responses (Bisogno et al.,

• To develop antagonists selective for the mouse

  2021-04-06

  

  To develop antagonists selective for the mouse EP1 receptor, we started with compound (), synthesized as previously described (). Diethyl dipicolinic 1145 () was reduced with NaBH to . Parikh–Doering oxidation of with sulfur trioxide–pyridine complex and DMSO produced the unstable aldehyde . 4-Chlo

• The MOF system described by

  2021-04-06

  

  The MOF system described by Farha and coworkers combines rational design of the support and good experimental results regarding activity and stability. However, a further increase in the speed of enzyme loading into the MOF and a decrease in leaching are still required. How can the design rules prop

• A number of chemical strategies have been

  2021-04-06

  

  A number of chemical strategies have been developed to design activatable optical imaging probes and have been summarized in several excellent reviews 11., 12., 13., 14., 15.. Fluorogenic enzyme substrates are one of the most explored activatable probe types for enzyme detection. These probes contai

• The Acat gene was identified by functional complementation o

  2021-04-06

  

  The Acat1 gene was identified by functional complementation of a Chinese hamster ovary cell mutant lacking ACAT activity [12]. Unlike most other genes, human Acat1 is located in two different chromosomes, EZLink NHS-Biotin Kit 1 and 7, with each site containing a distinct promoter: chromosome 1 co

• Canine ANGPTL7 / Angiopoietin-like 7 Protein (Fc Tag) A gro

  2021-04-06

  

  A growing body of data indicates that endothelial NOS (eNOS) is a rate-limiting enzyme for the synthesis of nitric oxide (NO), its downstream Canine ANGPTL7 / Angiopoietin-like 7 Protein (Fc Tag) molecule. High pathological concentrations of NO produced from inducible NO synthase (iNOS) induce apop

• Glycolysis is important to maintain the vital functions of T

  2021-04-06

  

  Glycolysis is important to maintain the vital functions of T. gondi. Extracellular T. gondii shift its Papain metabolism towards glycolysis, based on the observation that a relocation of glycolytic enzymes from the cytosol to the pellicle occurs at the time when tachyzoites egress from host cells.

• br Acknowledgements The research leading to these results ha

  2021-04-06

  

  Acknowledgements The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7-PEOPLE-2013-COFUND) under grant agreement no 609020 − Scientia Fellows (JB) and the Research Council of Norway (NFR-grant 221444) (JB, JPM, OB). Introduction Hu

• The present study was set to characterise the DNMT

  2021-04-06

  

  The present study was set to characterise the DNMT gene orthologs and describe the expression patterns of these genes during seed development in natural diploid apomict B. divaricarpa and diploid sexual B. stricta. Material and methods Results The B. stricta genome v1.2, was sequenced and ass

• br Experimental section br Results

  2021-04-06

  

  Experimental section Results and discussion Conclusions In conclusion, we have presented an autocatalytic recycling amplification electrochemical biosensing platform for simple, rapid and ultrasensitive detection of MTase activity by combining methylation-sensitive restriction endonuclease

• In conclusion we have recombinantly expressed

  2021-04-06

  

  In conclusion, we have recombinantly expressed and purified the product of the YP_002262821.1 gene from A. salmonicida and confirmed that it possesses ATP-dependent DNA ligase activity. Comparison of the full-length and truncated versions of the protein indicate that the N-terminal 25 GSK2606414 en

• Rufinamide mg br Acknowledgements br Introduction Serum trig

  2021-04-06

  

  Acknowledgements Introduction Serum triglyceride concentrations increase following ingestion of a fat containing meal resulting in postprandial hyperlipidemia. Peak serum triglyceride levels are observed within 2 to 4h of fat consumption and then gradually return to baseline levels within appr

• AP1903 Within the Class II receptors the Type

  2021-04-06

  

  Within the Class II receptors, the Type I IFN receptor subunit, IFNAR-1, is exceptional in having four tandem FNIII domains, denoted here D1–D4. This structure appears to have arisen as a tandem AP1903 of the basic D1/D2 structure; thus, D1 and D3 of IFNAR-1 are more closely related, as are D2 and

14055 records 619/937 page Previous Next First page 上5页 616617618619620 下5页 Last page