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br Acknowledgements br Introduction TB is also widely
2020-07-31
Acknowledgements Introduction TB is also widely prescribed as a stain to identify proteoglycans and glycosaminoglycans (GAGs) in agarose gel electrophoresis (Dietrich and Dietrich, 1976; Coulson-Thomas et al., 2015). In addition, as adjunct to a photodynamic antimicrobial chemotherapy assay, T
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GLPG0634 Introduction br Material and methods br Results br
2020-07-31
Introduction Material and methods Results Discussion The high degree of conservation of the prolyl-4-hydroxylase active site between the cone snail sequences and the Homo sapiens, Gallus gallus and Bos taurus prolyl-4-hydroxylase, suggests that only the hydroxylation prone proline residue
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To more fully explore the opportunity in this chemical
2020-07-30
To more fully explore the opportunity in this chemical space a series of compounds in which the carboxylic dna-pk inhibitor was replaced with neutral moieties were pursued. A number of design criteria were employed in selection of targets, including calculated properties cutoffs for polar surface ar
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Increased knowledge about CRC pathogenesis
2020-07-30
Increased knowledge about CRC pathogenesis has provided new and remarkable treatments beyond the classical options of surgery, radiation and chemotherapy [11]. Despite these advances, chemotherapy remains the most important element of anti-cancer therapy. Chemotherapy, when initiated, is generally e
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The genomic DNA sequences of CXCL and CXCRs were
2020-07-30
The genomic DNA sequences of CXCL8 and CXCRs were retrieved from the fugu genome database v4.0. The intron–exon boundaries were identified with the corresponding cDNA sequences. This comparison revealed that the fugu gene is about 1.13kb long and contains four exons separated by three introns (top
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Notably we made the novel observation that expression of the
2020-07-30
Notably, we made the novel observation that expression of the growth-promoting protein survivin was greatly downregulated in the ZD 9379 with KPT-185 treatment. Furthermore, the enhanced nuclear staining of survivin in Jeko-1 tumor sections visualized by immunohistochemistry indicated that survivin
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We further examined our hypothesis that the activation of CR
2020-07-30
We further examined our hypothesis that the activation of CRF and CCK systems is responsible for the enhanced anxiety-like behavior induced by immobilization stress using two antagonists to block the expression of CRF1 and CCK2 receptors. It was found that CCK2 receptor antagonist CR2945 or CRF1 ant
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We utilized a divide and conquer
2020-07-30
We utilized a “divide-and-conquer” approach to investigate, for the first time, the isolated catalytic and dimerization domains in CPG2. This was motivated in part by the quest for high-quality NMR peak shapes, and in part as an effort to reduce the immunogenicity of CPG2 by reducing the overall siz
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SC 79 After calculating all of the required parameters for v
2020-07-30
After calculating all of the required parameters for vapor-liquid equilibrium modeling, the solubility of SO2 was calculated in all of the investigated DESs. In order to have an evaluation of the two models of NRTL-CPA and UNIQUAC-CPA, the statistical error parameter of AARD% is defined as Eq. (42).
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br Materials and methods br Results and
2020-07-30
Materials and methods Results and discussion Concluding remarks The successful knockout of the tpi1 gene in K. pneumoniae DSM2026 and the physiological study of mutants grown on different carbon sources led to the discovery of a novel tpi2 gene in this bacterium. The direct enzyme assay and
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To more fully explore the opportunity in this chemical
2020-07-29
To more fully explore the opportunity in this chemical space a series of compounds in which the carboxylic Bax channel blocker was replaced with neutral moieties were pursued. A number of design criteria were employed in selection of targets, including calculated properties cutoffs for polar surfac
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br Acknowledgments br Introduction Polyphenols are aromatic
2020-07-29
Acknowledgments Introduction Polyphenols are aromatic molecules that contain multiple phenolic hydroxyl groups and are components of plant pigments with a bitter flavor. Polyphenols have been reported to be useful in anti-oxidative (Boots et al., 2008, Nakai et al., 2003) and anti-obesity (Ika
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Another potential use for CDK inhibitors
2020-07-29
Another potential use for CDK inhibitors in CLL is in the context of lymphocytosis that has plateaued during treatment with a BCR pathway inhibitor. Although it has recently been shown that patients with prolonged lymphocytosis following achievement of PR with lymphocytosis (PR-L) do not fare more p
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br Conclusion The results of the present
2020-07-29
Conclusion The results of the present study suggest that blockade of CRF1 and CRF2 receptors in the BLA and CeA reduces the duration of TI behavior, probably due to decreased fear and/or anxiety. It is possible that this effect of specific CRF receptor antagonists can occur by reduction of endoge
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PPAR expression showed no changes in
2020-07-29
PPARα Wortmannin showed no changes in all the developmental stages studied. Several works have shown decreased expression of ACO and CPT1 (targets of PPARα), together with clear markers of fatty liver disease [48], [49], [50], [51]. As PPARα activity regulates the expression of both CPT1 and ACO [36
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