• Also our data from this study

  2019-09-09

  

  Also, our data from this study indicate that gestational GC exposure altered hematological and hemorheological parameters, however reports exist that altered blood rheological markers are associated with atherosclerosis and CVD (Tzoulaki et al., 2007). Also, the platelet to lymphocyte ratio (PLR) ha

• To study the role of DNA PK in the

  2019-09-09

  

  To study the role of DNA–PK in the response to replication arrest, we used the DNA replication inhibitor aphidicolin (APH). APH, a mycotoxin isolated from Cephalosporium aphidicola, inhibits DNA replication by interacting with the replicating DNA polymerase α (pol α). APH specifically inhibits the a

• Hedamycin isolated from Streptomyces griseoruber belongs to

  2019-09-09

  

  Hedamycin, isolated from Streptomyces griseoruber, belongs to the highly cytotoxic pluramycin class of Nifedipine (Figure 3(c)). It consists of a planar anthrapyrantrione chromophore attached to two amino sugar rings at one end and a bisepoxide-containing side-chain at the other end (Figure 3(c)).

• Ingested folate needs to be chemically modified in

  2019-09-09

  

  Ingested folate needs to be chemically modified in order to become a one carbon donor for cell metabolism. Firstly, folate turns to dihydrofolic histone demethylase (DHF), it is then converted into tetrahydrofolate (THF) by the dihydrofolate reductase enzyme (DHFR) and finally converted into N5, N1

• br Conflict of interest br Acknowledgments Dr

  2019-09-09

  

  Conflict of interest Acknowledgments Dr. Hauger was supported by a BLR&D Merit Review grant from the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development. Dr. Hauger also received support from the VA Center of Excellence for Stress and Mental Healt

• br Acknowledgements br Introduction Anxiety and

  2019-09-09

  

  Acknowledgements Introduction Anxiety and depression are major components of maintaining the cycle of addiction, and are responsible for the negative reinforcement of drug seeking behaviors (Sarnyai et al., 1995, Koob and Le Moal, 2008). Both rats and humans exhibit increased anxiety states du

• br Benefits and risks of traditional combined oestrogen

  2019-09-09

  

  Benefits and risks of traditional combined oestrogen–progestogen HRT regimens Combined oestrogen–progestogen regimens were developed to reproduce the short- and long-term benefits of oestrogen replacement therapy (ERT) and to simultaneously provide appropriate protection against oestrogen-related

• We propose two hypotheses to interpret our findings

  2019-09-07

  

  We propose two hypotheses to interpret our findings. The first, ELR (+) CXC chemokines stimulate both CXCR-1 and CXCR-2 chemokine receptor while activating neutrophils; however CXCR-1 chemokine receptor seems to play more active role in the process of neutrophil migration as shown in previous studie

• Alternatively procedural factors may have contributed to

  2019-09-07

  

  Alternatively, procedural factors may have contributed to the conflicting results. For instance, in order to have a more circumscribed area of drug diffusion, a volume of 0.05μl was injected in experiment 1b, which is four times lower than the one used in the mentioned plus-maze investigation. Besid

• Although the findings detailed above provide ample evidence

  2019-09-07

  

  Although the findings detailed above provide ample evidence that the activity of the CRF1 receptor in the amygdala plays a role in the acute and chronic effects of alcohol exposure, several important areas of investigation remain understudied. The majority of the work on CRF1-alcohol interactions ha

• Secondary and primary studies have

  2019-09-07

  

  Secondary and primary studies have considered the decision to select the provider and to select components after the component origin is chosen. Examples of secondary and primary studies outside our scope, but still related to decision-making are listed in Tables 1 and 2. The secondary and primary s

• Several studies have already shown that mPR activation can s

  2019-09-07

  

  Several studies have already shown that mPR activation can significantly reduce intracellular cAMP levels in different kind of cells, such as GT1-7 neuronal cells [32], MDA-MB-468 breast cancer cells [55] and primary vascular endothelial cells [56]. The experiments performed with PTXa and 8-Br-cAMP

• NBI 27914 hydrochloride br The modulation of ER from SERMs t

  2019-09-07

  

  The modulation of ERα: from SERMs to TSECs Continued efforts to provide women with efficacious menopausal therapies have generated interest in the development of selective NBI 27914 hydrochloride receptor modulators (SERMs). Similar to estrogens, SERMs have been shown to bind to ERs with high af

• br Introduction Oral contraceptives OCs are

  2019-09-07

  

  Introduction Oral contraceptives (OCs) are the most commonly used medication for contraception all over the world and are also used in the treatment of menstrual disturbances and hyperandrogenism in women with polycystic ovary syndrome [1]. The impact of OC steroids on cardiovascular pathophysiol

• Recent studies have reported that miR plays an important

  2019-09-07

  

  Recent studies have reported that miR-454 plays an important role in various cellular processes and diseases, such as inflammation, infection, osteogenic differentiation, and cancers [25,27,29,30]. Multiple evidence has documented that miR-454 promotes the proliferation, migration and invasion, and

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